Continuous glucose monitoring (CGM) is vital for diabetes care, but current
systems rely on invasive implants or electrochemical sensors that often cause
discomfort and skin irritation. Non-invasive alternatives remain limited by low
sensitivity and poor compatibility with complex sweat environments,
highlighting the urgent need for a comfortable and reliable solution. Ici, we
report the development of a wearable optical sensor watch that integrates
surface plasmon resonance (SPR) technology with a functionalized silver-coated
silicon nanowire (Ag/SiNW) substrate for real-time, non-invasive glucose
monitoring in sweat. The nanostructured sensor is functionalized with
4-mercaptophenylboronic acid (4-MPBA), enabling selective glucose capture and
optical signal transduction through both Raman scattering and SPR shift. The
dual-mode detection strategy was systematically optimized, and a miniaturized
SPR system operating at 638 nm was successfully integrated into a wearable
watch format with wireless data transmission to a mobile application. Ce
wearable device demonstrated excellent sensitivity (LOD down to 0.12 mM) et
high selectivity in detecting glucose within physiological sweat concentration
ranges. Human subject trials confirmed its applicability in real-life
scenarios. This study offers a promising non-invasive alternative to
traditional CGM and highlights the potential of integrating nanophotonic
sensors with wearable platforms for continuous health monitoring and
personalized medicine.

Cet article explore les excursions dans le temps et leurs implications.

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