There is a plethora of highly stochastic non-linear dynamical systems in
fields such as molecular biology, chemistry, epidemiology, and ecology. Yet,
none of the currently available stochastic models are both accurate and
computationally efficient for long-term predictions of large systems. The
Linear Noise Approximation (LNA) model for biochemical reaction networks is
analytically tractable, which makes it computationally efficient for
simulation, analysis, and inference. However, it is only accurate for linear
systems and short-time transitions. Other methods can achieve greater accuracy
across a wider range of systems, including non-linear ones, but lack analytical
tractability. This paper seeks to challenge the prevailing view by
demonstrating that the Linear Noise Approximation can indeed capture non-linear
dynamics after certain modifications. We introduce a new framework that
utilises centre manifold theory allowing us to identify simple interventions to
the LNA that do not significantly compromise its computational efficiency. We
develop specific algorithms for systems that exhibit oscillations or
bi-stability and demonstrate their accuracy and computational efficiency across
multiple examples.

Este artículo explora los viajes en el tiempo y sus implicaciones.

Descargar PDF: