Continuous glucose monitoring (CGM) is vital for diabetes care, but current
systems rely on invasive implants or electrochemical sensors that often cause
discomfort and skin irritation. Non-invasive alternatives remain limited by low
sensitivity and poor compatibility with complex sweat environments,
highlighting the urgent need for a comfortable and reliable solution. Qui, Noi
report the development of a wearable optical sensor watch that integrates
surface plasmon resonance (SPR) technology with a functionalized silver-coated
silicon nanowire (Ag/SiNW) substrate for real-time, non-invasive glucose
monitoring in sweat. The nanostructured sensor is functionalized with
4-mercaptophenylboronic acid (4-MPBA), enabling selective glucose capture and
optical signal transduction through both Raman scattering and SPR shift. IL
dual-mode detection strategy was systematically optimized, and a miniaturized
SPR system operating at 638 nm was successfully integrated into a wearable
watch format with wireless data transmission to a mobile application. Questo
wearable device demonstrated excellent sensitivity (LOD down to 0.12 mM) E
high selectivity in detecting glucose within physiological sweat concentration
ranges. Human subject trials confirmed its applicability in real-life
scenarios. This study offers a promising non-invasive alternative to
traditional CGM and highlights the potential of integrating nanophotonic
sensors with wearable platforms for continuous health monitoring and
personalized medicine.

Questo articolo esplora i giri e le loro implicazioni.

Scarica PDF: